It is an interesting list. Surprisingly I have read 49, but like Ann, some of the series listed I've only read the first book (Outlander) or a couple of books (Patterson/Alex Cross) before not continuing, but I marked them anyway!

Certainly some of my all-time favorites are on the list: A Tree Grows in Brooklyn, To Kill A Mockingbird, Chronicles of Narnia, Hitchhiker's Guide, Little Women, Charlotte's Web, Pilgrim's Progress.
Several I hated: The Book Thief, Atlas Shrugged, 50 Shades, The Great Gatsby.
Gone With The Wind is the only book that would have been on a favorite list when I first read it way back, liked it less with a re-read after a few years, hated Scarlett so much by the 3rd read many years later that the whole book lost its appeal for me.

Quite a few others were required reading or extra credit reading in high school and I enjoyed most of them with no strong feelings one way or the other. I'm not even sorry I read the books I listed as "hated". Some I admit to reading just because they were talked about books through the years and I wanted to see what the fuss was about. Several of the newer novels I have seen the movies but not read the books, so there weren't too many books on the list I had never even heard of.
Is it called the Great American Read just because of American viewers of PBS? They certainly aren't just "American" books.