I cross all sorts of genre boundaries. I have historicals, contemporary suspense thrillers, fantasy, and space opera. Most don't cross over, but some do, and I've found it doesn't hurt me. Science fiction and fantasy, of course, have better crossover appeal than more divergent genres. The other key for you might be humor. If your blurbs have the same sort of voice and tone, and you can make this connection clear, then I think you'll improve your conversion rate.