The main consideration is serif or sans-serif. I believe the recommended option for e format is sans-serif but personally I prefer serif. There are arguments for and against, the original one being that sans-serif is easier to read on a screen. But the current argument against is that it's TOO easy to read and people are inclined to read too quickly, skim over things and not take in the content. As technical/academic books are popular in e form this is rather more of a concern than whether or not readers fully take in every detail of a novel.
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