I think it can "work" in terms of quality, but could be problematic when it comes to sales, as you might tend to lose potential readers from one of the two genres who have no interest in the other genre.
My personal favorite "blender" would be Roger Zelazny, many of whose books toe a precarious balance between fantasy and science fiction; and even those that are more clearly one or the other usually have at least some of the other. For me, in his case that tension between the genres is part of their magic -- along with his phenomenal writing skill.
As there seems to be a large overlap between readers of fantasy and sci-fi (and is probably the reason they tend to be lumped together in many book stores), this is probably one of the more fertile areas of genre cross-pollination.
My personal favorite "blender" would be Roger Zelazny, many of whose books toe a precarious balance between fantasy and science fiction; and even those that are more clearly one or the other usually have at least some of the other. For me, in his case that tension between the genres is part of their magic -- along with his phenomenal writing skill.
As there seems to be a large overlap between readers of fantasy and sci-fi (and is probably the reason they tend to be lumped together in many book stores), this is probably one of the more fertile areas of genre cross-pollination.