1.) Joss Whedon
2.) I cannot think of anybody to play Clade Josso, because Clade really doesn't look like the Hollywood actor muscle type. I guess the closest approximation would be somebody just out of their teen years who is handsome but looks like they've enjoyed a few cheeseburgers; not grossly overweight, but carrying a little more on him than your muscle-bound actor
For Radha I'd like somebody who is beautiful but more mature, like Diane Lane or Catherine Zeta-Jones. Somebody beautiful but not looking like a teeny bopper.
For Meru, I'd need somebody tall and thin, similar to a young Jeff Goldblum. Maybe even Adam Baldwin. Now that I think more... Adam, definitely.
For Alha, I'm thinking somebody with black hair who would look good with purple skin and orange eyes, with a light attitude (though not necessarily comedic). Maybe somebody like Mark Addy, only a bit thinner.
For Vord Passa, somebody with age, who is angular and can have a rough, nasty demeanor. John Glover
For the Blindmen, Sean Bean (Finally, a role in which he is not a bad guy, a knight, or killed!)
3.) I want an orchestral score done by either Michael Giacchino or Patrick Doyle. That being said, if there must be a pop song attached, I think I'd want either Kid Rock or P.O.D. doing it.